Sex Disparities in Arteriovenous Fistula Maturation Outcomes

Abstract

The end-stage kidney disease life-plan aims to individualize hemodialysis (HD) access selection in patients requiring renal replacement therapy. Paucity of data on risk factors for poor arteriovenous fistula (AVF) outcomes limits the ability of physicians to guide their patients on this decision. This is especially true for female patients, who are known to have worse AVF outcomes when compared to male patients. The goal of this study was to identify risk factors associated with poor AVF maturation outcomes in female patients that will help guide individualized access selection. A retrospective review of 1,077 patients that had AVF creation between 2014 and 2021 at an academic medical center was performed. Maturation outcomes were compared between 596 male and 481 female patients. Separate multivariate logistic regression models were created for the male and female cohorts to identify factors associated with unassisted maturation. AVF was considered mature if it was successfully used for HD for 4-week sessions without need for further interventions. Unassisted fistula was defined as an AVF that matured without any interventions. The male patients were more likely to receive more distal HD access; 378 (63%) male versus 244 (51%) female patients had radiocephalic AVF, P<0.001. Maturation outcomes were significantly worse in female patients; 387 (80%) AVFs matured in females and 519 (87%) in male patients, P<0.001. Similarly, the rate of unassisted maturation was 26% (125) in female patients versus 39% (233) in male patients, P<0.001. Mean preoperative vein diameters were similar in both groups; 2.8±1.1mm in male versus 2.7±0.97mm in female patients, P=0.17. Multivariate logistic regression analysis of the female patients revealed that Black race (odds ratio [OR]: 0.6, 95% confidence interval [CI]: 0.4-0.9, P=0.045), radiocephalic AVF (OR: 0.6, 95% CI: 0.4-0.9, P=0.045), and preoperative vein diameter <2.5mm (OR: 1.4, 95% CI: 10.33-0.901.1-1.7, P=0.014) were independent predictors of poor unassisted maturation in this cohort. In male patients, preoperative vein diameter <2.5mm (OR: 1.4, 95% CI: 1.2-1.7, P<0.001) and need for HD prior to AVF creation (OR: 0.6, 95% CI: 0.3-0.9, P=0.018) were independent predictors of poor unassisted maturation. Black women with marginal forearm veins may have worse maturation outcomes, and upper arm HD access should be considered when advising patients on their end-stage kidney disease life-plan.