Abstract
The lower serum urate concentration of age-fertile women compared to men is thought to be related to a higher renal clearance of urate possibly detrmined by plasma estrogen levels. We assessed renal handling of uric acid in 9 normal age-fertile women compared to 9 age-matched men. Women showed significantly lower serum urate concentrations than men (3.5 ± 0.3 vs. 4.9 ± 0.7 mg/dl, P < 0.001), higher fractional excretion of urate (9.8 ± 1.0 vs. 7.3 ± 0.8 percent, P < 0.001) and lower tubular urate postsecretory reabsorption (P <0.01). To test the hypothetical uricosuric effect of plasma E2 we administered estradiol valerate and estradiol benzoate to oophorectomized and age-fertile women, respectively. Plasma E2 levels and urinary total estrogen excretion increased significantly but failed to substantially modify serum urate or the fractional excretion of uric acid. Furthermore, in 4 normal age-fertile women tubular urate transport was not influenced by plasma E2 levels. The lower tubular urate postsecretory reabsorption of age-fertile women compared to men is in accordance with their lower serum urate concentration and higher fractinal excretion of uric acid. Plasma E2 does not influence renal handling of uric acid.
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