Abstract
THE survival time of skin allografts in mice incompatible at non H-2 histocompatibility loci is frequently shorter in females than in males1–3. As far as we know, comparable differences have not been observed for allografts of normal tissue incompatible at the H-2 locus, although the enhanced suppression of tumour growth by female hosts has been reported for both H-24 and non H-22,5 histoincompatibilities. In the normal animal, the mean survival time for grafts on male and female mice varies by less than a day in the combination CBA→strong A. This is true for our own strains, whose origin has been described6, and this does not seem to have been contra dieted. We have found, however, that when the recipients are treated with rabbit anti-mouse thymocyte serum (ATS) there are differences in the survival time for grafts on males and on females.
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