Sex differences in stress effects on response and spatial memory formation

Abstract

Stress and stress hormones are known to affect learning and memory processes. However, although effects of stress on hippocampus-dependent declarative learning and memory are well-documented, relatively little attention has been paid to the impact of stress on striatum-dependent stimulus–response (S–R) learning and memory. Recent evidence indicates that glucocorticoid stress hormones shortly after learning enhance S–R memory consolidation, whereas stress prior to retention testing impairs S–R memory retrieval. Whether stress affects also the acquisition of S–R memories in humans remains unclear. For this reason, we examined here the effects of acute stress on S–R memory formation and contrasted these stress effects with those on hippocampus-dependent spatial memory. Healthy men and women underwent a stressor (socially evaluated cold pressor test, SECPT) or a control manipulation before they completed an S–R task and two spatial learning tasks. Memory was assessed one week later. Our data showed that stress impaired S–R memory performance in men but not in women. Conversely, spatial memory was impaired by stress in women but not in men. These findings provide further evidence that stress may alter learning and memory processes beyond the hippocampus. Moreover, our data underline that participants’ sex may play a critical role in the impact of stress on multiple memory systems.