Sex differences in non-strangulated postoperative adhesive small bowel obstruction: a retrospective cohort study.

Abstract

Adhesive small bowel obstruction (ASBO) is one of the major causes of postoperative morbidity. Non-surgical management is generally applied to non-strangulated ASBO. Several factors have been reported to affect the response to non-surgical management in patients with ASBO. However, the association between sex differences and non-strangulated ASBO remains unclear. This study aimed to elucidate the effect of sex differences in non-strangulated postoperative ASBO. We divided 139 patients with a first episode of non-strangulated postoperative ASBO into two groups: male group (n=83) and female group (n=56). Clinical features and prognosis were compared between the two groups. Female patients had lower proportions of oesophageal/gastric malignancies (P=0.044) and colorectal malignancies (P=0.030) and a higher proportion of uterine/ovarian malignancies (P < 0.001) than male patients did. More female patients required surgical management than male patients (P=0.003) did. Hospital length of stay (LOS) was longer (P=0.046) in the female group than in the male group. Multiple logistic regression analysis showed that the female sex was associated with an increased risk of the need for surgical management (odds ratio 5.318, P=0.006). Cox proportional hazards regression analysis revealed that the female sex was positively associated with increased LOS (hazard ratio 0.687, P=0.045). Female sex was associated with failure of non-surgical management and increased LOS in patients with non-strangulated postoperative ASBO.