Abstract
Purpose: Females have a higher prevalence and burden of osteoarthritis (OA), reporting higher pain and poorer functional outcomes than males. Muscles crossing the knee joint are primary contributors to dynamic knee joint motion and loading during walking. Low knee extensor muscle strength in females is thought to play a role in knee OA initiation, but less well studied is its role in OA progression. Few studies have examined the interactive effects of sex on higher overall and prolonged muscle activation patterns that have been linked to knee OA severity and progression.
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