Abstract
The clastogenic effect of the antischistosomal drug hycanthone methanesulfonate was studied with the micronucleus test in mouse bone marrow cells. Male and female (102/ EI × C3 H/ EI) F 1 mice were treated with single i.p. injections. Bone marrow was sampled 18, 24 and 30 h after treatment with 100 mg/kg. The highest micronucleus yield occurred at 24 h. The dose response for micronucleus induction at 24 h after treatment was non-linear for doses between 5 and 300 mg/kg. The lowest effective dose was 5 mg/kg for females and 10 mg/kg for males. The experiments revealed a singificantly higher sensitivity of female mice for the induction of micronuclei in polychromatic erythrocytes by hycanthone methane-sulfonate. This result supports the recommendation to use both sexes for quantitative assessment of genotoxicity in the micronucleus test.
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