Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort.

Jonathan Hill,Nicola Wright,Elizabeth C. Braithwaite,Helen Sharp,Andrew Pickles

doi:10.1111/jcpp.13229

Abstract

BackgroundBased on previous findings from the Wirral Child Health and Development Study (WCHADS), and on evolutionary hypotheses, we preregistered analyses of data from a large epidemiological sample (https://osf.io/fn5g9/register/564d31db8c5e4a7c9694b2be), to test for sex‐dependent moderation by prenatal maternal depressive symptoms of the association between postnatal maternal depressive symptoms and child emotional problems.MethodsA total of 8,354 mothers and children were followed from pregnancy to 3.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). Self‐report measures of prenatal and postnatal maternal depressive symptoms, and maternal report of child emotional symptoms were administered.ResultsThere was a three‐way interaction between maternal prenatal and postnatal depression, and child sex (Coeff .042 95% CI 0.015 to 0.068, p = .002). This arose from moderation by prenatal depression, in opposite directions in boys and in girls. In boys, the association between postnatal depression and child emotional symptoms was weaker following lower prenatal depressive symptoms (interaction term coeff = .030, p = .001), and in girls, to a lesser extent, the association was stronger following lower prenatal depressive symptoms (interaction term coeff = −.012, p = .221).ConclusionsWe replicated the finding from the WCHADS that prenatal depression modifies the association between postnatal depression and children's emotional problems in a sex‐dependent fashion. In ALSPAC, the sex difference was explained mainly by a protective effect of low prenatal depression in boys, while in WCHADS, it arose from greater vulnerability of girls to postnatal depression following low prenatal depression. In the light of these findings, in evaluating and implementing early interventions, there is need to consider that risks associated with postnatal depression may vary depending on maternal mood during pregnancy and may differ between boys and girls.

Highlights

According to the ‘foetal origins’ hypothesis, foetal adaptations occur in utero in anticipation of later environmental exposures (Barker, 2007)
In Avon Longitudinal Study of Parents and Children (ALSPAC), the sex difference was explained mainly by a protective effect of low prenatal depression in boys, while in Wirral Child Health and Development Study (WCHADS), it arose from greater vulnerability of girls to postnatal depression following low prenatal depression
In WCHADS, the sex difference was accounted for largely by the vulnerability of girls exposed to the sequence of low prenatal anxiety or depression, followed by high postnatal exposure, which we interpreted as reflecting a lack of the anticipatory effect of high prenatal maternal symptoms

Summary

Introduction

According to the ‘foetal origins’ hypothesis, foetal adaptations occur in utero in anticipation of later environmental exposures (Barker, 2007) This theory was first proposed to account for associations between low birth weight and later obesity, cardiovascular disease and type II diabetes, whereby low birthweight reflects an evolved adaptive mechanism that confers advantages in later environments of food scarcity, but simultaneously creates risk in the presence of a high-calorie diet. Results: There was a three-way interaction between maternal prenatal and postnatal depression, and child sex (Coeff .042 95% CI 0.015 to 0.068, p = .002) This arose from moderation by prenatal depression, in opposite directions in boys and in girls. In ALSPAC, the sex difference was explained mainly by a protective effect of low prenatal depression in boys, while in WCHADS, it arose from greater vulnerability of girls to postnatal depression following low prenatal depression.

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