Sex differences in chick eye growth and experimental myopia

Abstract

Stimulated by reported sex differences in eye size and refraction in humans, we compared refractions and ocular size measurements of male and female chicks. Chicks were reared under a 12-hr light/dark cycle with one eye open and the other occluded by a goggle or lid suture, each well-established means of inducing ipsilateral myopia. While the open eyes of the two sexes emmetropized equally well, both ultrasound and caliper measurements demonstrated that on average males have larger eyes. Although statistically significant for defined populations, the sex differences in open eyes were to small to be diagnostic for individual birds. The visually-deprived eyes of male chicks were more reactive than those of females, especially following deprivation by a goggle. Consistently, the anterior chamber of visually-deprived eyes of males was deeper than those of the females regardless of the means of impairing vision. With a goggle, males also developed more myopia and a deeper vitreous chamber than females similarly occluded. When goggles were removed, rapid recovery occurred in 2 weeks irrespectively of sex.