Sex Differences in Blunt Traumatic Aortic Injury from the Aortic Trauma Foundation Global Registry

Abstract

Trauma is the leading cause of death in people younger than 45 years, and blunt traumatic aortic injury (BTAI) is the second leading cause of death after blunt trauma. There have been reports on variations in physiological response to trauma between men and women, as well as sex/gender disparities in aortic disease outcomes, but there is a gap in the literature on sex differences in patients with traumatic aortic injury. The Aortic Trauma Foundation international prospective multicenter registry was used to examine sex differences in traumatic aortic injury characteristics, management, and outcomes from 2016 to 2022. Data were analyzed by contingency table, stratified and multivariable regression. There were 781 patients with BTAI and complete injury grade information, of whom 182 patients (23%) were female. The mean age was 43.4 ± 18 years, and women were significantly older than men (48 ± 18.6 vs 42.3 ± 17.6 years, P < .0001). A total of 464 patients (59%) underwent thoracic endovascular aortic repair with no significant difference between men (61%, 364 of 599) and women (55%, 100 of 182). Injury severity score and Glasgow coma scores did not differ between women and men. Women more often had pelvic fracture (41% vs 30%, P < .004), splenic injury (31% vs 23%, P < .05), renal injury (22% vs 14%, P < .02), sacral spine fracture (12% vs 6%, P < .02), and sternal fracture (17% vs 10%, P < .02), but these injury patterns were not associated with higher grade aortic injuries. There were no sex differences in the distribution of aortic injury grade. In-hospital mortality was 12%, and aortic-related mortality was 4% for the entire cohort, with no differences between men and women. The presence of sternal fracture appeared to predict higher aortic mortality in women (10% with sternal fracture vs 2% without, P = .05) but not in men (9% with sternal fracture vs 10% without P = .9). There is no difference in mortality between men and women with BTAI. Women with BTAI presented more frequently with intra-abdominal and pelvic injuries, and sternal fractures appear to predict a higher mortality in women with BTAI.