Sex differences and other correlations of Human Corpus Callosum: A review

Abstract

AbstractThere is a wide spectrum in the field of sex differences and other correlation in human corpus callosum. More recent literatures have raised doubts as to whether the anatomic size of the corpus is actually different. The aim of this review article is to bring out the actual facts about gender distinction and various associations in human corpus callosum. Related literatures in the subject were reviewed through electronic database like PubMed, NCBI, Google Scholar, Web of science and conclusion was derived comparing the similarities, dissimilarity and relationship of corpus callosum. A simple ratio of corpus callosum to whole brain size is not an appropriate way to analyse data and can create a false impression of dimorphism in the corpus callosum. Overall no sex difference could be found in the size of the corpus callosum, whether ornot explanation was taken oflarger male brain size. RecentMRI studies showed no difference in thickness of the corpus callosum when accounting for the size of the subject. The corpus callosum has been reported to be larger in musicians, left-handed persons whereas smaller in children with dyslexia. Hypogenesis, dysgenesis and agenesis of corpus callosum are rare congenital anomalies presented with feeding problems and delays in holding the head erect during sitting, standing & walking; and impairments in mental & physical development, hand-eye coordination and visual & auditory memory.