Abstract
BackgroundFew studies investigate sex difference in stroke incidence in rural China hypertensive population.MethodsA total of 5097 hypertensive patients aged ≥35 years (mean age, 56.3 ± 11.2 years; 43.8% men) were included in our analysis with a median follow-up 8.4 years in Fuxin county of Liaoning province in China. Cox proportional hazard models were used to analyze the association between the potential factors and incident stroke.ResultsWe observed 501 new strokes (310 ischemic, 186 hemorrhagic, and 5 unclassified stroke) during the follow-up. The overall incidence of stroke was 1235.21 per 100,000 person-years; for men, the rates were 1652.51 and 920.80 for women. This sex difference in all stroke can be explained by approximately 25% through age, systolic blood pressure, body mass index, low-density lipoprotein-cholesterol, current smoking, current drinking, antihypertensive drugs, education and physical activity. Subgroup analysis indicated that in hemorrhagic stroke this sex difference was more remarkable (63.89% can be explained).ConclusionsThe incidence of stroke was higher in men than that in women and this difference was partly explained by several traditional cardiovascular risk factors.
Highlights
Few studies investigate sex difference in stroke incidence in rural China hypertensive population
Subgroup analysis shows that the incident rates of ischemic and hemorrhagic stroke were 1078.72 and 568.05 per 100,000 person-years in men and 527.41 and 367.10 per 100,000 person-years in women
The incidence of stroke and its subtypes were higher in men than that in women (Fig. 2)
Summary
Few studies investigate sex difference in stroke incidence in rural China hypertensive population. Another population-based study in Sweden found stroke incidence to be 60% lower for women than men at ages 55–64 years, but by the age of 75 years women had a 50% higher incidence than men [13] Most of these studies were conducted in Western countries and the data about the sex difference in stroke incidence in China was scarce. Few studies have quantitatively investigated the potential factors that affect this disparity [7, 8] Understanding this sex difference and its influence factors can help us prevention stroke better
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