Abstract
Fasting serum-free fatty acid (FFA) and blood glucose levels were measured in 57 healthy subjects and in 80 untreated diabetic subjects. The response of the serum-FFA level to the rapid intravenous injection of glucose (1.0 g/kg0.7) was examined in 33 healthy subjects and in 57 untreated diabetic subjects. The effect of treatment of diabetes with Lente insulin, sulfonylureas and phenformin (phenethyl biguanide) upon the serum-FFA levels and responsiveness was examined in 16, 4 and 7 subjects, respectively. A distinct sex difference was observed in both the fasting serum-FFA level and its responsiveness to glucose. In healthy men the fasting serum-FFA level was lower, and its response to glucose less, than in healthy women. In diabetic men the fasting serum-FFA level did not increase as the fasting blood glucose level increased, and was only slightly elevated even when severe fasting hyperglycemia was present. In diabetic women the fasting serum-FFA level did increase as the fasting blood glucose level inc...
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