Abstract
This study sought to define the sex-difference in trabecular and cortical bone parameters in Vietnamese individuals. The study involved 1404 women and 864 men aged between 20 and 86 years who were recruited from Ho Chi Minh City, Vietnam. Trabecular and cortical volumetric BMD were measured at the proximal tibia and proximal radius at 4%, 38%, and 66% points, using a peripheral quantitative computed tomography XCT2000 (Stratec, Germany). Polar strength strain index was estimated from cortical bone parameters. Changes in bone parameters were assessed by the multiple linear regression model. Among individuals aged 20–39 years, women had significantly lower peak trabecular BMD at both the radius (40%) and tibia (16%) than men, but the age-related reduction in trabecular BMD were similar between two sexes. For cortical BMD, peak values in women and men were comparable, but the age-related diminution was greater in women than men. At any age, polar strength strain index in women was lower than men, and the difference was mainly attributable to cortical bone area and total bone mass. We conclude that in the elderly, sex-related difference in trabecular BMD is originated during growth, but sex-related difference in cortical BMD is determined by differential age-related bone loss.
Highlights
At any given age, women have higher risk of fracture than men[1]
ABMD measurement has served the management of osteoporosis in clinical setting very well, it suffers from some limitations
Peripheral quantitative computed tomography is a relatively new technology that can overcome the limitations of the dual-energy X-ray absorptiometry (DXA) technology
Summary
Women have higher risk of fracture than men[1]. Factors underlying this gender-related difference are not well documented[2]. ABMD measured by DXA does not distinguish between cortical and trabecular bone, in which their relative composition contributes differently to bone strength. Previous studies have shown that cortical and trabecular structure parameters were strongly correlated with bone strength, and could help predict the risk of fracture in postmenopausal women[12,13,14,15]. We sought to define the age-related changes in BMD, bone structural parameters and bone strength in men and women of Vietnamese background
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