Abstract
Retinal hydroxyindole-O-methyl transferase (HIOMT) activity exhibited maximal valuesduring proestrus in rats. Castrated female rats showed lower retinal HIOMT activities than intactrats in proestrus. Estradiol benzoate administration (0.01 to 1 µ⁄day) reversed the ovariectomy-induced changes in retinal HIOMT. Pinealectomy in 30 days-old male rats resulted in increases of retinal HIOMT activity, that could be correlated with increases in testicular weight and plasma testosterone levels. These results suggest that estradiol and testosterone are involved in the regulation of retinal HIOMT activity in the rat. (Endocrinology 94: 294, 1974)
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