Abstract
Sex is a key biological variable that has been shown to influence both physiology and disease. A growing body of research suggests that sex differences occur in respiration and brain physiology. This study examines how sex impacts changes in spatial memory and hippocampal synaptic plasticity following CIH, a model of sleep disordered breathing. Adult mice (>P30) of both sexes were either exposed to 0 days (control) or 10 days of CIH. On the final four days of CIH, mice were trained and tested in a Barnes maze apparatus. Glutamatergic synaptic transmission in area CA1 was recorded in hippocampal brain slices harvested from control and CIH mice. CIH exposure increased the latency for locating the exit in both sexes during the probe trial; however, only females showed increased variability in performance. Following CIH, long term potentiation (LTP) was depressed in both male and female mice. While no sex differences were observed in LTP, our ongoing experiments suggest that paired pulse facilitation (PPF) after CIH increases in females.Support or Funding InformationThe University of Chicago, Faculty Diversity Career Advancement GrantThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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