Abstract
There is evidence that sex- and gender-related factors are involved in cannabis patterns of use, health effects and biological mechanisms. Women and men report different cannabis use disorder (CUD) symptoms, with women reporting worse withdrawal symptoms than men. The objective of this systematic review was to examine the effectiveness of cannabis pharmacological interventions for women and men and the uptake of sex- and gender-based analysis in the included studies. Two reviewers performed the full-paper screening, and data was extracted by one researcher. The search yielded 6098 unique records—of which, 68 were full-paper screened. Four articles met the eligibility criteria for inclusion. From the randomized clinical studies of pharmacological interventions, few studies report sex-disaggregated outcomes for women and men. Despite emergent evidence showing the influence of sex and gender factors in cannabis research, sex-disaggregated outcomes in pharmacological interventions is lacking. Sex- and gender-based analysis is incipient in the included articles. Future research should explore more comprehensive inclusion of sex- and gender-related aspects in pharmacological treatments for CUD.
Highlights
Growing evidence related to the importance of sex- and gender-based factors within health research has led to increased interest among researchers, funding agencies, scientific journals and database creators to find innovative ways of examining these factors in previously unexplored areas [1,2,3]
In this systematic review on sex- and gender-related factors in cannabis pharmacological interventions, there was a paucity of studies that sex-disaggregated outcomes for women and men or analyzed the sex- or gender-related factors in the interventions
Overall the findings showed that the pharmacological interventions analyzed in the studies are not effective for treating cannabis use disorder (CUD), three of the four included studies found different results for women and men
Summary
Growing evidence related to the importance of sex- and gender-based factors within health research has led to increased interest among researchers, funding agencies, scientific journals and database creators to find innovative ways of examining these factors in previously unexplored areas [1,2,3]. The integration of sex- and gender-related factors into research, policy, or health programs revisits or identifies the influence of components such as anatomy, physiology, genetics and other bodily characteristics biological (sex-based) and the social and cultural milieu affecting humans socio-cultural (gender-based) is known as sex- and gender-based analysis (SGBA) [4]. Randomized controlled trials (RCT) provide the strongest research evidence and are often used to test the efficacy of new pharmacological interventions. Sex- and gender-based analysis in RCTs is very scarce. In a study that analyzed 100 Canadian-led or funded
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
