Abstract
Simple SummaryThe study assessed the content of macroelements Ca, Mg, P, and Na in the proximal femoral bone tissue in patients with hip osteoarthritis, and it correlated with age, sex, and BMI. The high reduction of macroelements in the femoral bone of patients with hip osteoarthritis is more pronounced in the cortical bone and occurs in women under 60 years of age. In men, it begins in the seventh and increases in the eighth decade of life. Background: The content of macroelements in bones varies with age and depends on sex. The aim of the study was to evaluate the content of macroelements and its correlation with age and sex in the femoral bone obtained during total hip arthroplasty. Methods: In the 86 patients, the content of macroelements (Ca, P, Mg, and Na) in the femoral head and neck (cancellous and cortical bone) was assessed by means of the inductively coupled plasma optical emission spectrometry analytical technique (ICP-OES). Results: There was a decrease in the content of macroelements in the cortical bone with age in the women in the 51–60 years (statistically significant: −0.59 for Ca, −0.65 for P) and over 70 years age groups (correlation not statistically significant: −0.29 for Ca, −0.38 for P). A significant decrease in the content of macroelements in the cortical bone was found in men over 70 years of age. Conclusions: Patterns of increased loss of macronutrients (Ca, P, and Mg) in the femoral neck (cortical bone) were demonstrated in the following patients with osteoarthritis: women aged 51–60 years and patients of both sexes over 70 years of age.
Highlights
Bone remodeling is age- and sex-dependent—women tend to lose more bone mass with age than men [1]
The aim of the study was to assess the dynamics of changes in the content of macroelements (Ca, P Mg, and Na) in the cancellous and cortical femoral bone in the successive decades of life in women and men who had undergone primary total hip arthroplasty (THA) without fractures
The Ca concentration in the women showed a similar trend of changes in the femoral head and the femoral neck, assuming lower values in the 51–60 years group
Summary
Bone remodeling is age- and sex-dependent—women tend to lose more bone mass with age than men [1]. In women, it begins in the third or fourth decade of life, with its maximum in the menopausal period [2]. Starting in the seventh decade of life in women and about ten years later in men, a decrease in bone mineral density (BMD) was observed with a disturbance of the bone microarchitecture, increasing the frequency of fractures [3]. Conclusions: Patterns of increased loss of macronutrients (Ca, P, and Mg) in the femoral neck (cortical bone) were demonstrated in the following patients with osteoarthritis: women aged 51–60 years and patients of both sexes over 70 years of age
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