Severity of comorbid osteoarthritis is not associated with increased risk for incident diabetes mellitus

Abstract

s / Osteoarthritis and Cartilage 20 (2012) S54–S296 S187 Objective: Although there is evidence for a beneficial effect of increased quadriceps strength on knee symptoms, the effect on knee structure is unclear. This study examined the relationship between change in vastus medialis (VM) cross-sectional area (CSA) and knee pain, tibial cartilage volume and risk of knee replacement in subjects with symptomatic knee osteoarthritis (OA). Methods: 117 subjects with symptomatic knee OA had a knee MRI at baseline, 2 years, and 4.5 years. VM CSA was measured at baseline and 2 years. Tibial cartilage volume was measured at baseline, 2 years, and 4.5 years. Knee pain was assessed by the Western Ontario and McMaster University Osteoarthritis Index at baseline and 2 years. Knee joint replacement over 4 years was determined. Results: Baseline VM CSAwas inversely associated with current knee pain (r1⁄4-0.16, P1⁄40.04) andmedial tibial cartilage volume loss from baseline to 2 years (B1⁄4-11.2, 95% CI -20.1 to -2.4), but not baseline tibial cartilage volume. In addition, an increase in VM CSA from baseline to 2 years was associated with reduced knee pain over the same time period (r1⁄40.25, P1⁄40.01), reduced medial tibial cartilage loss from 2 to 4.5 years (B1⁄4-16.8, 95%CI -28.9 to -4.6), and reduced risk of knee replacement over 4 years (OR1⁄40.61, 95%CI 0.40-0.94). Conclusions: In a symptomatic knee OA population, increased VM size was associated with reduced knee pain and beneficial structural changes at the knee, suggestingmanagement of knee pain and optimizing VM size are important in reducing OA progression and subsequent knee replacement. 369 SEVERITY OF COMORBID OSTEOARTHRITIS IS NOT ASSOCIATED WITH INCREASED RISK FOR INCIDENT DIABETES MELLITUS G.A. Hawker , R. Croxford , A. Bierman , P. Harvey , L. Lipscombe . Women's Coll. Hosp., Toronto, ON, Canada; 2 Inst. For Clinical And Evaluative Sci., Toronto, ON, Canada; Univ. of Toronto,