SEVERITY AND MORTALITY PREDICTION IN ACUTE PARAQUAT POISONING BY SERUM PARAQUAT QUANTITIVE TEST

Abstract

Introduction: Acute paraquat poisoning is common in Vietnam. Mortality and severity prediciton of acute paraquat poisoning patient is difficult. Serum paraquat concentration is a useful prognostic fatal value. Objective: Apply quantitative test for serum paraquat concentration to determine the severity and prognose in acute paraquat poisoning patients. Subjects and methods : An observational analytic study included acute paraquat poisoning patients were treated at Poison Control Center of Bach Mai hospital from 4/2015 to 5/2016. Results: 92 patients were included, with 52.6% males and 47,4% females. The average age of the patients was 34.2 ± 14.5. Fifty-two patients were reported dead (62.37%). The patients classifed as survial group were detected to get serum paraquat concentration to be significantly lower than other patients in dead group (2.6 ± 4.92 in comparision with 23.8 ± 27.64, p<0.001), serum paraquat concentration was not correlated with PSS level (p>0.05). SIPP scale was evaluated to be efficient in dead prognosis. The AUROC of SIPP scale was 0.860, p<0.001 (95% CI: 0.782 – 0.938). The value of SIPP = 15 had highest sensitivity and specificity (0.750, 0.767, respectively). Conclusion: Serum paraquat concentration was determined the effective values in estimating the severity and dead prognosis. SIPP Scale was useful for mortality prognosis. Key words: Acute Paraquat poisoning, serum Paraquat concentration