SEVERITY AND FREQUENCY OF MITRAL REGURGITATION IN PATIENTS PRESENTING WITH ACUTE MYOCARDIAL INFARCTION

Abstract

Objective: The aim of our study was to determine the frequency and severity ofMR in patients presenting with STEMI after emergency reperfusion treatmentwith primary percutaneous coronary Intervention (P-PCI) or streptokinase (SK)during hospital stay. Methodology: This cross-sectional study was conducted at National Institute ofCardiovascular Diseases (NICVD), Karachi for six month of duration from 1stAugust 2013 to 31st January 2014. Patients of both genders aged between 20-60 years presenting with STEMI who underwent emergency reperfusion therapywith primary percutaneous coronary Intervention (P-PCI) or streptokinase (SK)were included in the study. Descriptive analyses were performed for socieodemographiccharacteristics while Chi-square test was applied for theassociation of different characteristics among various categories of mitralregurgitation. Results: Total of 262 patients were included in the study with mean age of53.9±7.1 years. Of them 68% of the patients were males. Mitral regurgitation(mild, moderated and severe) with different characteristics was found in 58%(152) patients .Elderly patients with acute inferior wall MI (IWMI) and thosereceiving SK were more likely to have MR. Furthermore patients with IWMI andthose receiving SK were more likely to suffer from severe grade ofMR(p 0.05). Conclusion: MR is a frequent complication of STEMI and it was more frequent inpatients with IWMI or who received SK as a mean of emergency thrombolysis. Key Words: ST Elevation Myocardial Infarction, Mitral Regurgitation,Streptokinase, Primary PCI