Severe topical corticosteroid withdrawal syndrome or enigmatic drug eruption?

Abstract

We recently read with great interest the report authored by Nguyen et al1 regarding a possible severe topical corticosteroid (TCS) withdrawal syndrome (TCWS) case presenting in an adult with chronic atopic dermatitis using low-dose topical corticosteroids. TCWS is a rare entity, with the current literature remaining sparse and exhibiting low quality of evidence. As discussed in the National Eczema Association systematic review of topical corticosteroid withdrawal, this distinct clinical adverse event is likely correlated to the improper use of TCSs.