Severe Reversible Renal Failure Induced by Recombinant Human Granulocyte Colony-Stimulating Factor in a Child with Chronic Acquired Agranulocytosis

Abstract

Human granulocyte colony-stimulating factor (hG-CSF) is a glycoprotein which, in conjunction with other colony-stimulating factors, controls myelopoiesis [1–3]. Recombinant (r) hG-CSF and natural hG-CSF have similar effects in vitro. In man, rhG-CSF causes marked increases in peripheral blood neutrophil counts within 4 h. Elevations of neutrophil counts are dose dependent at recommended doses. Neutrophils produced in response to rhG-CSF show normal function [4]. Following termination of rhG-CSF therapy, circulating neutrophil counts decrease by 50% within 2 days and to baseline levels within 1 week [5, 6].