Abstract
In the treatment of syphilis with arsenicals and heavy metals, the therapeutic shock, or so-called Jarisch-Herxheimer reaction, has been observed, and we have noted the same type of reaction in 2 lepers with the lepromatous type of the disease who were being treated with diasone (disodium formaldehyde sulfoxylate diaminodiphenylsulfone). This drug, newly adopted in the therapeutics of leprosy, is given credit for the encouraging results we have been achieving. We have had the opportunity to study one of the first cases of this reaction to occur with the application of this drug. Pfuetze and Pyla 1 reported a case of a severe reaction of the pemphigoid type observed in a tuberculous patient under treatment with diasone. The pemphigoid eruption was followed by exfoliating dermatitis. Muir, 2 reporting on his treatment of 12 lepers with diasone, did not refer to any reaction resulting from the application of this drug. At the
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