Abstract
The use of imipramine in the treatment of childhood enuresis has recently gained wide acceptance. The drug is known to be quite toxic to children who accidentally ingest it.1-4 Instances of incapacitating toxic effects caused by therapeutic dosages of the drug have not, to the best of our knowledge, been reported in children. It is our purpose to report a case of severe postural hypotension associated with therapeutic dosages of this drug. Report of a Case A 9-year-old Caucasian female was evaluated because of enuresis which had been present since toilet training was begun at age 2 years. A complete history and physical examination were nonrevealing; her pulse was 82 beats per minute and blood pressure was 110/75 mm Hg.
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