Abstract
Waldenström’s macroglobulinemia (WM), characterized with monoclonal immunoglobulins of type M and lymphoplasmacytic lymphoma, is a rare clonal Bcell disorder. WM usually present as an indolent lymphoma, and renal involvement is, in contrast to multiple myeloma, very rarely seen. We present a patient presenting with severe nephritis and nephrotic range proteinuria of more than 9 g/day as initial manifestations of WM. Furthermore, we discuss diagnostic and therapeutic approaches for this rare manifestation of the disease, in the light of recent research and treatment recommendations.
Highlights
The patient was a 65 years old woman, which primary medical history included a mild aortic valve stenosis and conservative treated arthrosis in hip and knee joints. She had no previous history of renal disease, and displayed a normal ranged creatinine value eight months prior to admission
We present a patient presenting ia with severe nephritis and nephrotic range proteinuria of more than 9 g/day as initial c manifestations of Waldenström’s macroglobulinemia n (WM)
In the present case report we describe a with lymphoplasmacytic lymphoma /WM.[6] deposits along the glomerular basement
Summary
The patient was a 65 years old woman, which primary medical history included a mild aortic valve stenosis and conservative treated arthrosis in hip and knee joints She had no previous history of renal disease, and displayed a normal ranged creatinine value eight months prior to admission. Com Introduction n- Waldenström’s macroglobulinemia (WM), defined as the presences of monoo clonal immunoglobulins of type M (IgM) N and ≥10% clonal lymphoplasmacytic cells lic taste in the mouth, and increased dyspnea and headache, most pronounced in the morning. The blood test confirmed anemia, acute kidney failure, extensive proteinuria, hyperproteinemia with elevated monoclonal IgM and kappa light chains. Kappa light chains and and general B-symptoms could occur.[2] typing revealed a clonal expansion with the IgM were detected in walls of small. Electron microscopy examination uncommon.[5]
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