Abstract
Neonatal sepsis is a major cause of neonatal mortality and morbidity in preterm, very low birth weight infants. Coagulase-negative staphylococcus and Candida spp. are among the most common causes of single infections and coinfections in neonates. Candida lusitaniae is rarely reported as an opportunistic pathogen in very low birth weight neonates. Early diagnosis and appropriate antifungal therapy can prevent morbidity and mortality in preterms especially in coinfections. Necrotizing enterocolitis is one of the most catastrophic gastrointestinal emergencies in premature infants in the intensive care neonatal unit, especially in preterm infants. Currently, the pathogenesis of necrotizing enterocolitis is believed to have multifactorial causes. We present the case of a very low birth weight preterm who developed necrotizing enterocolitis and sepsis caused by a coinfection of Coagulase-negative Staphylococcus and Candida lusitaniae.
Highlights
Neonatal sepsis is a major cause of neonatal mortality and morbidity in preterm, very low birth weight infants
The prevalence of neonatal sepsis is inversely correlated with gestational age and birth weight and the survivors can have an increased risk of short and long neurologic sequelae [4 - 7]
We present a case of a preterm that developed lateonset sepsis after coinfection with Coagulase-negative staphylococcus (CoNS) and Candida lusitaniae
Summary
A 39-year-old patient, gravida 4, para 3, diagnosed with thrombophilia and preeclampsia was admitted in a level. III maternity at 29 weeks and 6 days, 8 days prior to birth. She received treatment for pregnancy induced hypertension (PIH). The mean blood pressure remained high (170/110 mmHg) as it did not respond to treatment and cesarean section was performed at 31 weeks of gestation. She had negative peripheric and central cultures throughout the pregnancy, prior, during the hospitalization and after birth. The infant was admitted in the NICU, placed at the thermal neutrality point in an incubator and received oxygen therapy as heated humidified high flow oxygen nasal canula, FiO2 of 0.25, parenteral nutrition (TPN), prophylactic antibiotherapy (Penicillin and Colimycine)
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