Abstract
Severe Malaria and Artesunate Treatment, Norway
Highlights
With the exception of 1 patient who had become infected while in Myanmar, all patients acquired falciparum malaria in West Africa (Table)
In the United States, artesunate for infusion may be obtained as an investigational drug from the Centers for Disease Control and Prevention, and in the European Union, artesunate recently received the Orphan Medicinal Drug Designation from the European Medicines Agency and may be obtained from IDIS Pharma
If falciparum malaria is acquired at the Cambodia–Thailand border region, artesunate resistance should be considered; except for this region, where mefloquine resistance is a problem, artesunate is considered to be an efficacious drug with limited reports of resistance
Summary
With the exception of 1 patient who had become infected while in Myanmar, all patients acquired falciparum malaria in West Africa (Table). A major obstacle for the use of IV artesunate is its poor availability outside Asia and the fact that its use is not approved in many countries. In the United States, artesunate for infusion may be obtained as an investigational drug from the Centers for Disease Control and Prevention
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