Abstract

A 58-year-old female patient took orlistat 0.12 g orally once daily by herself due to obesity. After 13 months, she developed fatigue and anorexia. Laboratory tests showed alanine aminotransferase(ALT) 1 603 U/L, aspartate aminotransferase(AST) 1 265 U/L, alkaline phosphatase(ALP) 310 U/L, direct bilirubin(DBil) 8.4 μmol/L, and indirect bilirubin(IBil) 13.4 μmol/L. She was diagnosed with liver injury. Orlistat was discontinued, considering its relationship with the liver injury. And an IV infusion of diammonium glycyrrhizinate 150 mg (added to 250 ml of glucose injection) once daily was given. Two days later, the diammonium glycyrrhizinate was replaced by IV infusion of magnesium isoglycyrrhizinate 100 mg (added to 100 ml of 0.9% sodium chloride injection) once daily because that the symptoms did not relieve. After 6 days of treatment with magnesium isoglycyrrhizinate, the patient′s symptoms relieved and she had ALT 124 U/L, AST 73 U/L, ALP 73 U/L, DBil 3.1 μmol/L, and IBil 7.3 μmol/L. After 1 month, liver function tests showed ALT 30 U/L, AST 57 U/L, ALP 93 U/L, DBil 3.0 μmol/L, and IBil 11.8 μmol/L. Key words: Liver; Drug-related side effects and adverse reactions; Drug-induced liver injury; Orlistat

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.