Abstract
BackgroundKawasaki disease is a multi-system vasculitis which usually occurs in children under 5 years of age. In infants under three months of age, it is very rare and usually associated with a high incidence of incomplete or atypical forms, often unresponsive to treatment. This condition increases the risk of cardiovascular complications such as coronary artery aneurysms.Case presentationWe describe a 3-month-old infant who developed early and severe aneurysms in three coronary arteries despite a timely administration of intravenous immunoglobulins, followed by three days of intravenous methylprednisolone.ConclusionThis case report underlines that the development of coronary artery aneurysm correlates with a delayed diagnosis and treatment, incomplete or atypical forms of the disease, and additionally the severity of clinical presentation, especially in cases of very young infants below 3 months of age. Our case is notable because of the very young age of the patient, the severity of clinical presentation with an early development of coronary artery aneurysms and the unresponsiveness to the therapy.
Highlights
Kawasaki disease is a multi-system vasculitis which usually occurs in children under 5 years of age
This case report underlines that the development of coronary artery aneurysm correlates with a delayed diagnosis and treatment, incomplete or atypical forms of the disease, and the severity of clinical presentation, especially in cases of very young infants below 3 months of age
We describe a case of a 3-month-old male infant with Kawasaki disease (KD) who developed severe coronary artery lesions despite an early diagnosis and a timely administration of intravenous immunoglobulin (IVIG)
Summary
Our case is notable because of the very young age of the patient, the severity of clinical presentation with an early development of coronary artery aneurysms and the unresponsiveness to the therapy. Consent Written informed consent was obtained from the parents of the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the editor-in-Chief of this journal. Competing interests The authors declare that they have no competing interests. Authors’ contributions All the authors participated sufficiently in preparation of this manuscript SL, PB, GG, VD–followed the patient in his clinical course. GFP and SL–took care of the revisions of the Ms SL, ML–made the final analysis and critical revision of this Ms All authors gave final approval for manuscript publication
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