Abstract
Intracranial hemorrhage (ICH) is the second leading cause of mortality among patients diagnosed with acute myelogenous leukemia (AML). The bone marrow failure associated with AML produces dysfunctional platelets, which significantly increases the risk of hemorrhagic complications within this population. In this report we discuss the case of a previously healthy female patient, newly diagnosed with AML, who rapidly developed fatal ICH.
Highlights
Intracranial hemorrhage (ICH) is the second leading cause of mortality in patients with acute myelogenous leukemia (AML).[1]
The bone marrow failure associated with AML produces dysfunctional platelets, which significantly increases the risk of hemorrhagic complications within this population
Pathogenesis of disseminated intravascular coagulation (DIC) in patients with acute promyelocytic leukemia (APL) is mediated by increased blast cell production of tissue factor (TF) and cancer procoagulant (CP), and blast cell overexpression of the surface protein annexin II, which acts as a co-receptor for plasmin and tissue plasminogen activator, leading to extensive fibrinolysis.[16]
Summary
Severe Intracranial Hemorrhage at Initial Presentation of Acute Myelogenous Leukemia. Intracranial hemorrhage (ICH) is the second leading cause of mortality among patients diagnosed with acute myelogenous leukemia (AML). The bone marrow failure associated with AML produces dysfunctional platelets, which significantly increases the risk of hemorrhagic complications within this population. In this report we discuss the case of a previously healthy female patient, newly diagnosed with AML, who rapidly developed fatal ICH. In this report we discuss the case of a previously healthy female patient, newly diagnosed with AML, who rapidly developed fatal ICH. [Clin Pract Cases Emerg Med. 2018;2(3):203–206.]
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