Severe Infusion‐Related Reaction to Liposomal Amphotericin B

Abstract

ABSTRACTAimTo describe a case of severe infusion‐related reaction to liposomal amphotericin B (LAB).Clinical detailsA severely immunocompromised 58‐year‐old male with acute myeloid leukaemia experienced 2 infusion‐related adverse events when treated with LAB for a localised Fusarium solani fungal infection of the right forefoot. The initial adverse reaction to LAB was not serious. However, the second adverse reaction following a re‐challenge was serious. The patient had a poor prognosis because of the likelihood of further chemotherapy‐induced neutropenia and a potentially untreated disseminated fungal infection in light of planned chemotherapy.OutcomesLAB was successfully substituted with conventional amphotericin B to treat Fusarium solani infection. No adverse events were observed with conventional amphotericin B.ConclusionThe patient is suspected to have had a reaction to the lipid carrier of LAB.