Abstract
Twenty patients suffering from severe hypertension associated with renal failure have been treated with Minoxidil. Ten patients, not on RDT, had a residual Creatinine clearance between 7-71 ml/min; 10 were on hemo-dialytic treatment. Before starting on Minoxidil, all patients had been unsuccessfully treated with an association of traditional anti-hypertensive drugs (blood pressure 200.24/125.6 mmHg). Minoxidil administration dramatically lowered the blood pressure in all cases. After 1 week of treatment the mean decrease in DBP was 22.7%; after 1 month 28.1%, and after 3 months 32.9%. At 6, 12, and 18 months the results were substantially unaltered. Minoxidil dosage ranged from 5 to 50 mg/day over the initial phase; by the third month the daily dose was between 5 and 25 mg/day. Previous anti-hypertensive drugs were suspended in all cases and not subsequently resumed. Furosemide and Propranolol were the only exceptions to counteract the Minoxidil induced fluid retention and tachycardia. The main side effec...
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