Abstract
We investigated an outbreak of unexpectedly severe histoplasmosis among 14 healthy adventure travelers from the United States who visited a bat-infested cave in Nicaragua. Although histoplasmosis has rarely been reported to cause serious illness among travelers, this outbreak demonstrates that cases may be severe among travelers, even young, healthy persons.
Highlights
We investigated an outbreak of unexpectedly severe histoplasmosis among 14 healthy adventure travelers from the United States who visited a bat-infested cave in Nicaragua
A case of acute histoplasmosis was defined as illness in a person who tested positive by one of the following laboratory tests: serology, urine antigen, histopathology, or culture
Immunodiffusion and complement- fixation serologic tests were performed at the Centers for Disease Control and Prevention (CDC)
Summary
We investigated an outbreak of unexpectedly severe histoplasmosis among 14 healthy adventure travelers from the United States who visited a bat-infested cave in Nicaragua. A case of acute histoplasmosis was defined as illness in a person who tested positive by one of the following laboratory tests: serology, urine antigen, histopathology, or culture. Urine antigen tests, which were performed 2 weeks after exposure, are considered positive if >1 unit is detected [3,4].
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