Severe Gastrointestinal Bleeding due to Angiodysplasia after Transcatheter Aortic Valve Implantation in a Patient with High Frailty; What about Antiplatelet and Anticoagulant Therapy

Abstract

<p style="margin: 0cm 0cm 0pt; text-align: justify; line-height: 200%; text-indent: 35.4pt;"><span style="font-family: 'Times New Roman','serif';"><span style="font-size: medium;">Severe aortic stenosis is associated with significant morbidity and mortality if untreated. The transcatheter aortic valve implantation(TAVI) is now feasable and effective gold standart treatment option in patients with severe aortic valve stenosis(AS) and associated with similar rate of major adverse events compared to the surgery. The relation between </span><span style="font-size: medium;">aortic stenosis and gastrointestinal angiodysplasia was known as Heyde’s Syndrome since 1958. High fluid shear stress through the narrowed valve is thought to be the underlying mechanism leads to the mechanical disruption of the large von Willebrand factor multimers. Aortic valve replacement either surgical or with TAVI seems to reduce gastrointestinal bleeding in approximately 80% in patients with Heyde syndrome in whom gastrointestinal bleeding is associated with intestinal angiodysplasia due to acquired von Willebrand’s disease (type 2A) and aortic valve stenosis. The patients especially with atrial fibrillation who need anticoagulant therapy may have bleeding risk despite aortic valve replacement. We report a case of patient presenting with a massive intestinal bleeding originating from intestinal angiodysplasia after percutaneous aortic valve replacement. </span></span></p>