Abstract
ABSTRACT.Brain infarcts located in strategic regions often result in cognitive impairment. Based on a case study, this paper describes unusual and specific clinical and neuropsychological features of a strategic ischemic lesion in the left medial temporal lobe (MTL) structures. Taken together with the literature data, the case illustrates that a unilateral strategic infarct in MTL structures may result in severe impairment of episodic memory (EM), which refers to the ability to encode and retrieve personal experiences, including information about the time and place of an event and detailed description of the event itself. The preservation of other cognitive functions, the severe functional impairment, and the type of visual-verbal deficit in a left-sided lesion were identified as singular features of the case. The current case supports the critical role of the MTL structures in EM formation.
Highlights
The occurrence of strategically located ischemic vascular lesions in brain areas critical for cognition and behavior is referred to as strategic infarcts (SI).[1]
Clinical features of impairment in episodic memory (EM) may be observed in lesions that are more limited to the medial temporal lobe (MTL) region.[8]
This paper reports a case of severe episodic memory impairment as a result of focal ischemic lesion in the left MTL structures, contrasting and discussing unusual and specific clinical and neuropsychological features: (1) impairment of verbal and visual mnemonic modalities in a left-sided lesion; (2) preservation of other cognitive functions; and (3) severe functional impairment
Summary
The occurrence of strategically located ischemic vascular lesions in brain areas critical for cognition and behavior (e.g., associative, limbic, paralimbic circuitry) is referred to as strategic infarcts (SI).[1]. Clinical features of impairment in EM may be observed in lesions that are more limited to the medial temporal lobe (MTL) region.[8] data concerning alterations in EM associated with SI in the MTL structures are lacking. This paper reports a case of severe episodic memory impairment as a result of focal ischemic lesion in the left MTL structures, contrasting and discussing unusual and specific clinical and neuropsychological features: (1) impairment of verbal and visual mnemonic modalities in a left-sided lesion; (2) preservation of other cognitive functions; and (3) severe functional impairment.
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