Abstract

tropics and subtropics-areas that have become popular tourist destinations. In some case series, dengue is the second most frequent cause of hospitalization (after malaria) among travelers returning from the tropics [2]. GeoSentinel is a global provider-based surveillance network of travel medicine providers (available at: http://www.istm.org/geosentinel/ main.html); in its most recent update, dengue was the most frequent cause of systemic febrile illness in travelers to Asia [3]. The World Health Organization (WHO) classifies symptomatic dengue virus infections into 3 categories: undifferentiated fever, classic dengue fever, and dengue hemorrhagic fever (DHF) (figure 1) [4]. Dengue fever is defined clinically as an acute febrile illness with >2 manifesta-

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