Abstract
Antifungal creams had been used to treat clinically or mycologically diagnosed infections with dermatophytes or intertrigo. Seven to 21 days after initiation of antifungal therapy, the patients developed widespread eczema as well as erythematous, maculopapular, erythema multiformelike and blistering eruptions, that occurred in addition to intense eczematous reactions at application sites associated with peripheral blood eosinophilia, suggesting drug reactions (Fig. 1). After the eruptions had resolved, patch testing was performed with the European baseline, antimycotic agent, corticosteroid, preservative, and emollient series (Almirall Hermal, Reinbek, Germany) and culprit antifungal and corticosteroid creams used by the patients on Finn Chambers® on Scanpor® tape (SmartPractice, Phoenix, AZ, USA) applied for two days, with readings at D3 and D4. Five patients were sensitized to tixocortol pivalate or prednisolone. Two patients showed sensitization to both corticosteroids and clotrimazole, as well as to the culprit antifungal
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