Abstract
BackgroundAdenovirus is a common pathogen of acute upper respiratory infection in children and is generally self-limiting. Severe adenovirus infections have been reported in immunocompromised hosts especially bone marrow transplantation recipients due to hematologic malignancy. Severe adenovirus pneumonia in immunocompetent hosts has rarely been reported and optimal treatment has not been established. We report a case of community-acquired severe adenovirus pneumonia which was successfully treated with early administration of oral ribavirin.Case presentationA 39 year-old, previously healthy Korean male was admitted with symptoms of cough, myalgia, febrile sensation. Laboratory findings revealed that he had hypoxemia, thrombocytopenia and elevated transaminase. Chest imaging showed a consolidation with pleural effusion, which was rapidly progressed. All microbiological tests were negative except multiplex real-time reverse transcriptase polymerase chain reaction using respiratory specimen, which was positive for human adenovirus. Under the diagnosis of severe adenovirus pneumonia, we started oral ribavirin, which results in complete recovery without any complications.ConclusionsThis case demonstrates that oral ribavirin, instead of other expensive antiviral treatment, could be a good therapeutic option for the severe adenovirus pneumonia at least occurred in immunocompetent hosts.
Highlights
Adenovirus is a common pathogen of acute upper respiratory infection in children and is generally self-limiting
This case demonstrates that oral ribavirin, instead of other expensive antiviral treatment, could be a good therapeutic option for the severe adenovirus pneumonia at least occurred in immunocompetent hosts
We report a case of severe adenovirus pneumonia occurring in a previously healthy man which was successfully treated with oral ribavirin
Summary
Adenovirus is a common pathogen of acute upper respiratory infection in children and is generally self-limiting. Conclusions: This case demonstrates that oral ribavirin, instead of other expensive antiviral treatment, could be a good therapeutic option for the severe adenovirus pneumonia at least occurred in immunocompetent hosts. *Correspondence: humanmd04@hanmail.net 2 Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea Full list of author information is available at the end of the article have occasionally been reported among military recruits and adults in long-term care facilities or hospital wards, which included some fatal cases [2,3,4].
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