Abstract
Chrysosporium species are saprophytic filamentous fungi commonly found in the soil, dung, and animal fur. Subcutaneous infection caused by this organism is rare in humans. We report a case of subcutaneous fungal infection caused by Chrysosporium keratinophilum in a 38-year-old woman. The patient presented with severe chromoblastomycosis-like lesions on the left side of the jaw and neck for 6 years. She also got tinea corporis on her trunk since she was 10 years old. Chrysosporium keratinophilum was isolated from the tissue on the neck and scales on the trunk, respectively. The patient showed satisfactory response to itraconazole therapy, although she discontinued the follow-up.
Highlights
Chrysosporium species are saprophytic filamentous fungi occurring in soil, dung, animal fur, and bird feathers (Hocquette et al, 2005)
Chrysosporium species according to the current definition either reside as saprobes in habitats enriched with keratin such as bird feathers and animal hair when related to Onygenaceae (De Hoog et al, 2000; Hubalek, 2000), or cause skin infections in reptiles when affiliated to Nannizziopsiacea (Stchigel et al, 2013)
Chrysosporium keratinophilum is the anamorph of Aphanoascus keratinophilus, which is a member of Onygenaceae (Vidal et al, 2000)
Summary
Chrysosporium species are saprophytic filamentous fungi occurring in soil, dung, animal fur, and bird feathers (Hocquette et al, 2005). Cutaneous Infection by Chrysosporium keratinophilum she was admitted to our hospital She had a history of tinea corporis when she was 10 years old; at that time, other family members had the similar problem. Scales lesion from trunk revealed septate hyphal elements. A biopsy taken from the lesion on the neck showed suppurative granulomata formation, and septate hyphal elements were found in the dermis and pus upon PAS (Periodic Acid-Schiff) staining (Figures 2A,B). Direct microscopy of exudates from the lesion on the neck and scales on the trunk revealed septate hyphal elements (Figures 1C,D). Both clinical specimens were cultured on potato dextrose agar (PDA) at 25◦C for up to 2 weeks. The molecular investigation confirmed the mycological diagnosis and histopathological data led to the final diagnosis of chronic cutaneous granulomatous infection due to Chrysosporium keratinophilum
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