Severe cardiovascular disease and Alzheimer's disease: Senile plaque formation in cortical areas

Abstract

The main objectives of this study were to analyze the distribution of senile plaques (SP) and neurofibrillary tangles (NFT) in different cortical areas of patients suffering from severe cardiovascular diseases (CVD) and to compare them with Alzheimer's disease (AD) cases. Forty brains were divided into three groups: an AD group (n = 12), a CVD group (n = 17), and a nonheart disease control group (n = 11). The cortical areas examined were the middle frontal gyrus, the superior and inferior watershed areas, the hippocampal formation with the transentorhinal cortex, and the primary visual cortex. SP and NFT were counted in Bielschowsky-stained sections from all cortical areas and from the hippocampal formation and the transentorhinal cortex, respectively. Patients with severe CVD occupied an intermediate position in the spectrum of SP formation between AD and nonheart disease patients. The CVD group showed a higher prevalence of SP than the control group, and SP counts were significantly larger in the inferior watershed area, dentate gyrus, subiculum, and transentorhinal cortex. The distribution of SP was similar in CVD and AD patients. Control and CVD patients showed no difference regarding the number of NFT. The existence of a possible cardiovascular component in the genesis of SP is discussed. © 1996 Wiley-Liss, Inc.