Abstract
Clinical trials of the BNT162b2 mRNA (Pfizer–BioNTech) and ChAdOx1 nCoV-19 adenoviral (Oxford–AstraZeneca) vaccines showed high efficacy against symptomatic infection; however, evidence continues to emerge regarding protection against severe disease, hospitalisation, and death under real-world conditions. In December, 2020, the vaccines were approved in Scotland and rolled out, starting with health-care workers and the most vulnerable populations. At the time, the UK vaccination programme advised an extended dosing interval of 8–12 weeks, rather than the shorter 3-week interval used in the trials, to maximise coverage with a first dose quickly amid restricted vaccine supply.
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