Abstract
Background Aortic stenosis is characterized by impaired myocardial perfusion reserve due to coronary microvascular dysfunction. T1 mapping is sensitive to myocardial water content of both intra- and extracellular in origin, but the effect of intravascular compartment changes on T1 has never been assessed previously. We aimed to assess the effect of adenosine-induced vasodilatation on native (pre-contrast) T1 values in patients with severe aortic stenosis (AS) before and after aortic valve replacement (AVR).
Highlights
Aortic stenosis is characterized by impaired myocardial perfusion reserve due to coronary microvascular dysfunction
We aimed to assess the effect of adenosine-induced vasodilatation on native T1 values in patients with severe aortic stenosis (AS) before and after aortic valve replacement (AVR)
AS patients had increased resting myocardial T1 (1196 ±47 ms vs. 1168±27ms, p=0.037), reduced MPRI (0.92 ±0.31 vs. 1.74±0.32, p
Summary
Severe aortic stenosis has blunted myocardial T1 relaxation response to vasodilator stress: a cardiac magnetic resonance adenosine stress test study. Masliza Mahmod1*, Stefan K Piechnik, Eylem Levelt, Vanessa M Ferreira, Jane M Francis, Andrew Lewis, Nikhil Pal, Houman Ashrafian, Stefan Neubauer, Theodoros D Karamitsos
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