Abstract
We report a case of a male patient with Hodgkin's lymphoma and severe acne-like lesions associated with taking amineptine, a tricyclic antidepressant. The lesions appeared after self-administration of high doses of the drug, up to 4000 mg/day. The relationship between the acne-like lesions, drug intake and lymphoma are discussed. The severity of these cutaneous lesions seems to be correlated with the degree of overdose. A high concentration of lactam metabolites found in the lesions may explain their persistence. Drug addiction and alcoholism seem to be adjunctive risk factors for amineptine side-effects. The effect of amineptine may be facilitated by the presence of Hodgkin's disease.
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