Abstract
The potency of several new benzodiazepines as inhibitors of [ 3H]flunitrazepam binding was investigated in membranes from rat cerebellum or hippocampus. It was found that quazepam and two of its metabolites have a higher affinity for benzodiazepine receptors in cerebellum than for those in hippocampus, indicating a preferential interaction of these compounds with BZ 1-receptors. Other experiments indicated that these compounds have benzodiazepine agonistic properties similar to diazepam or flunitrazepam. Thus, for the first time, benzodiazepines have been identified which differentially interact with different benzodiazepine receptors.
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