Abstract
Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase gene (LIPC) −250G > A, endothelial lipase gene (LIPG) 584C > T, methylenetetrahydrofolate reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T > C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 978 normal weight and 751 overweight/obese subjects. The interactions were detected by factorial regression analysis. The genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT; LDL-R A-A- and LIPC GA; and SCARB1 TT were interacted with overweight/obesity to increase systolic, diastolic blood pressure (SBP, DBP) and pulse pressure (PP) levels; respectively. The genotypes of ACAT-1 CC; ACAT-1 AA and CC were interacted with overweight/obesity to decrease SBP, PP levels (p < 0.01–0.001); respectively. The differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of several SNPs and overweight/obesity.
Highlights
Hypertension is an emerging risk factor that causes more than 7.1 million premature deaths a year worldwide [1], and that is becoming more prevalent in developing nations [2]
We hypothesized that the differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of some single nucleotide polymorphisms (SNPs) and overweight/obesity in this population
The levels of education, weight, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) A1, ApoB, and the percentages of subjects who consumed alcohol were higher in overweight/obese than in normal weight subjects (p < 0.05–0.001), whereas the levels of serum high-density lipoprotein cholesterol (HDL-C), the ratio of ApoA1 to
Summary
Hypertension is an emerging risk factor that causes more than 7.1 million premature deaths a year worldwide [1], and that is becoming more prevalent in developing nations [2]. It is well known that blood pressure levels are regulated by multiple environmental and genetic factors and their interactions [3,4,5,6]. Recent genome-wide association studies in different populations have explored more than 160 candidate genes associated with blood pressure and hypertension, but the results of these association studies conducted with blood pressure traits are inconsistent [7,8,9,10]. A major reason for inconsistency among these studies may be different environmental modifiers that interact with genes to influence blood pressure and hypertension. The prevalence of obesity has dramatically increased during recent years in all parts of the world [12]. According to the World Health Organization (WHO), more than 400 million adults were obese in 2005, and it is estimated that more than 700 million adults will be obese by 2015 [13]
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