Abstract
It had been a great honor for me to work with the late Dr. William E. Paul for 17 years in the Laboratory of Immunology (LI) from 1998 until his passing in 2015. He was such a master in the immunology field. Under his outstanding guidance, my research has been focusing on transcriptional regulation of T helper (Th) cell differentiation, especially, on the role of a master transcription factor GATA3 during Th2 cell differentiation. Just as enormous scientific contributions of Dr. Paul (we all call him Bill) to the immunology community are far beyond his serving as the Chief of the LI, GATA3 also plays important roles in different lymphocytes at various developmental stages besides its critical functions in Th2 cells. In this special review dedicated to the memory of Bill, I will summarize the research that I have carried out in Bill’s lab working on GATA3 in the context of related studies by other groups in the field of T cell differentiation and innate lymphoid cell (ILC) development. These include the essential role of GATA3 in regulating Th2/ILC2 differentiation/development and their functions, the critical role of GATA3 during the development of T cells and innate lymphoid cells, and dynamic and quantitative expression of GATA3 in controlling lymphocyte homeostasis and functions.
Highlights
CD4 T helper (Th) cells orchestrate adaptive immune responses by producing effector cytokines
We hypothesized that GATA3, the critical factor for type 2 immune responses, may be functionally important for the generation of type 2 cytokine-producing innate-like lymphocytes
We have recently reported that GATA3 and Bcl11b form a complex and they co-localized in many enhancer regions within the Th1- and Th2-related genes [85]
Summary
CD4 Th cells orchestrate adaptive immune responses by producing effector cytokines. In order to effectively exert their protective functions during infections, distinct Th subsets are developed to deal with a variety of pathogens [10,11,12]. CRITICAL ROLE OF GATA3 IN Th2 DIFFERENTIATION AND FUNCTIONS CRITICAL ROLE OF GATA3 IN ILC2 DEVELOPMENT AND FUNCTION We hypothesized that GATA3, the critical factor for type 2 immune responses, may be functionally important for the generation of type 2 cytokine-producing innate-like lymphocytes.
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