Abstract
Abstract From the twigs of Eurycorymbus cavaleriei, seven new benzeneacetic acid derivatives cavaol A–G (1–7) were isolated. The structures were elucidated on the basis of the results of spectroscopic (NMR, IR, UV and MS) analysis. In the present study, the quinone reductase (QR) induction activities of compounds 1–7 were assayed. Compounds 3 and 4 showed moderate QR induction with concentrations to double the enzyme activity (CD) of 9.9 ± 0.3 and 7.9 ± 0.5 μg/mL, respectively. LC-MS-MS analysis revealed that the quinone reductase induction activity of compounds 3 and 4 was not due to alkylating the sulfhydryl groups of Keap1. There must be some other pathways for compounds 3 and 4 to induce quinone reductase.
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