Abstract
Around 1% of adults in the UK have rheumatoid arthritis (RA).1 UK national guidelines recommend that such people should receive disease-modifying anti-rheumatic drugs (DMARDs) as soon as possible after diagnosis, as earlier treatment is more effective in reducing disease progression.2<sup>,</sup>3 Also, it has been proposed that combination DMARD therapy may reduce joint damage more than single drugs.1<sup>,</sup>2<sup>,</sup>4 In the light of several recently published trials on combination therapy in early RA,5–14 here we update our recommendations on such treatment. 15<sup>,</sup>16
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