Abstract
Biomaterials The successful growth of large tissues requires the formation of a vascular system to ensure the proper supply of nutrients to the growing cells. One route to angiogenesis in the growing tissue is through the delivery of growth factors such as VEGF, but clinically this method has limitations. An alternative is to harness proangiogenic cells, such as blood-derived CD133+ cells, also known as circulating angiogenic cells (CACs). Parlato et al. used a cell invasion assay to optimize a hydrogel designed to recruit CACs over a period of 24 hours. Although hydrogel degradability and hydrogel stiffness—two known variables often connected with cell behavior—were found to be important in attracting CACs, a key third factor was the presentation of a gradient of stromal derived factor 1. Acta Biomat. 10.1016/j.actbio.2017.03.048 (2017).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
